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Cannabidiol (CBD) is one of the major compounds found in Hemp. Unlike THC, the other major cannabinoid in the cannabis plant, CBD is nonpsychoactive—which means it doesn’t give you the “high”. CBD is proven to assert its positive effects on the CNS allowing a person to feel relaxed minus the buzz.
While other cannabinoids interact with two significant receptors in our Endocannabinoid System namely CB1 and CB2, CBD has a mild and indirect effect on both of them. This mainly explains its non-psychotropic properties.
Yet from one research to the other, CBD is proven to have an array of benefits on the brain and the nervous system as a whole. Numerous studies have validated its neuroprotective actions- hindering the development of Alzheimer’s disease, its anti-depressant and anxiety-lowering effects, and its potential for treating epileptic seizures-just to name a few.
CBD’s mechanism involves various molecular pathways and binds with other receptor families which makes this wonderful compound a “multi-target” drug. Although CBD doesn’t have direct affinities to cannabinoid receptors CB1 and CB2, it impacts different receptor-independent channels, either inhibiting or facilitating specific protein-coupled receptors and their actions.
CBD targets the serotonin 1A receptor inducing many therapeutic effects. Because CBD offers relief without the “intoxicated” feeling it has become an ideal supplement to promote general health and well-being.
If you remember, serotonin receptors are responsible for the release of the stress hormone cortisol, which gets elevated as a reaction to stress.
By activating the serotonin 1A receptors, CBD inhibits certain problems and disorders such as anxiety, depression, seasonal affective disorder, and schizophrenia.
It also affects oxytocin levels which in turn influences social behavior. And since the Serotonin pathway is also responsible for a person’s mood, cognition, and appetite, count on Bliss CBD Oil to boost your mood, enhance focus, and regulate your appetite!
CBD attaches to TRPV1 receptors also known as capsaicin or vanilloid receptors to achieve a therapeutic effect. TRPV1 is also expressed at high levels in the central nervous system and has been proposed as a target for treatment of conditions such as anxiety.
Bliss CBD effectively eliminates the “jitters” by modulating TRPV1 in the central nervous system, while TRPV1 in the peripheral nervous system acts a target for pain relief alleviating those bothersome aches and pains!
GPR55 is implicated as a novel cannabinoid receptor because it is activated by endogenous, plant and synthetic cannabinoids. This has led some groups to suggest GPR55 should be categorised as the CB3 receptor, which may eventually follow. GPR55 mRNA is expressed in several brain areas as the hippocampus, hypothalamus, frontal cortex and cerebellum and was linked to CBD’s anti-seizure, anti-epileptic activity.
It is involved in the process of modulating blood pressure, bone reabsorption, and bone density.
By impeding GPR55 activity, Bliss CBD has the ability to reduce inflammation and neuropathic pain.
GPR55 activation is considered to have metastatic or cancer proliferating effects. Some studies have illustrated that CBD’s ability to block GPR55 activity explains its anti-tumor effects!
Peroxisome proliferator activated receptors (PPARs) are classified as “nuclear receptors,” which means they are located on the surface of the cell’s nucleus. CBD asserts its action on these receptors to produce anticancer activity by stimulating a receptor known as PPAR-gamma. This triggers an anti-proliferative effect and has been shown to cause tumors to regress in cases of lung cancer.
Researches show that CBD in the brain impedes the reuptake and breakdown of Anandamide- a major cannabinoid that the human body produces and an extremely powerful, THC-like chemical in the brain.
This increases endocannabinoid levels in the brain’s synapses producing neuroprotective action against seizures and other problems. More interestingly, Anandamide is also called the “bliss molecule,” aptly named after ananda, the Sanskrit word for “joy, bliss, or happiness.”
Bliss CBD, by indirectly increasing Anandamide levels in the brain, sustains a calm and focused disposition that will enable us to be in a state of “FLOW” where we FEEL our BEST and PERFORM our BEST.
In recent years, Cannabidiol has been steadily showing enormous potential in terms of a variety of medical applications. It is therefore vital to recognise the properties of CBD particularly its various effects on the human body.
As we seek to understand this unique compound and explore its many uses, our scientific community can come up with novel ways of utilizing CBD to improve the public’s overall health and well-being, once and for all eliminating the stigma that comes with cannabis use.